Everyday engineering practice in the area of structural glass design is facing some limitations regarding the optimisation of selected glass structures. Since laminated glass is a composite of brittle glass and polymeric interlayer, the behaviour of different types of interlayer, bond between them needs to be investigated. Modelling laminated glass is complex because of the linear elastic material behaviour of the glass in combination with the highly non-linear interlayer which is also a timetemperature-dependent polymer. In this work, numerical analyses of laminated glass panels exposed to four-point bending are performed to observe and compare the stresses and displacements caused by different parameters, such as temperature, load duration, the thickness and type of the interlayers, as well as the symmetrical and nonsymmetrical disposition of the glass plates’ thickness. A parametric study on these influences was performed. To obtain the relationship between the load duration, temperature, and thickness of the interlayer compared to the maximal displacement (as a measure of flexural stiffness) and tension stress in the bottom glass plate, an analytical polynomial of a sixth total order is proposed. Isosurfaces are created, showing the dependence of stresses and displacements on the specified parameters as well as clearly showing differences in the behavior of laminated glass panels for the same conditions but with different interlayers such as ethylene vinyl acetate (EVA), polyvinyl butyral (PVB) and Ionoplast. Based on the findings of the parametric study, conclusions are derived about the flexural stiffness and stress distribution in two-plate laminated glass with EVA, PVB and Ionoplast.