Polyvinyl butyral (PVB) is probably the most commonly and traditionally used elastomeric interlayer for laminated glass (LSG). For high-demanding applications, such as stairs, overhead glazing, and railings, the application of structural interlayers of high stiffness, e.g. SentryGlas Ionoplast, increases the safety of the laminated glass. However, Ionoplast interlayers require some special processing. For example, in the case of multi-ply laminations, a chemical treatment of glass by a primer is needed for proper adhesion to the air side of the glass. It is well verified that the adhesion between the PVB-based interlayer and the glass is mainly generated by the formation of hydrogen bonds between the hydroxyl groups of the two materials. Ambient air atmospheric plasma generated by diffuse coplanar surface barrier discharge (DCSBD) was studied for surface activation of PVB and SentryGlas Ionoplast interlayers and glass. The carried-out experiments show a very significant 60 % growth of average breaking force observed in the bending tests of LSG laminated using the plasma-activated glass and PVB film. In the case of SentryGlas Ionoplast interlayer, it was studied if plasma surface treatment can enhance the adhesion to the air side of the float glass. The results show the potential of DCSBD atmospheric plasma technology for the activation of interlayers considering that the DCSBD plasma sources can be easily integrated into commercial lamination lines.