ETAG002 and ASTM C 1401 are the main international Standards providing regulations for design of silicone joints in Structural Sealant Glazing (SSG) applications. They provide calculation methods with reference to flat glass units with regular (rectangular, trapezoidal or triangular) shape, in vertical position, bonded along all sides to load-bearing profiles and subject to wind load, dead load and temperature variations. Aforementioned Standards do not provide any recommendation for design of SSG joints in other system configurations, which are well-established solutions in the façade industry. It is the case, among others, of elements which are inward and outward sloped, not bonded along all sides, flat as well as curved and with irregular shape and subject to different load types (e.g. barrier loads, snow loads, maintenance loads, blast loads, etc.). In this paper, an advanced calculation method developed by Sika is presented to design SSG joints exposed to any kind of stress (tensile, shear and bending). Such calculation method correlates the strength offered by the adhesive to the duration and simultaneity of any load applied with the result of being applicable to any system configuration. The experience gained by Sika on bespoken projects is shared with practical examples.